Issue 2, 2017

Heteropoly blue doped polymer nanoparticles: an efficient theranostic agent for targeted photoacoustic imaging and near-infrared photothermal therapy in vivo

Abstract

With the development of personalized medicine, the research of theranostic agents with good biocompatibility, stability, and targeting properties remains meaningful. Herein, we report a two-step process to construct heteropoly blue (HPB) doped polymer nanoparticles (HPB/P4VP-b-PEO NPs) with efficient near-infrared (NIR) light absorption and photothermal conversion efficiency of ∼23% to simultaneously perform photoacoustic imaging and photothermal therapy in vivo. After intravenous injection into the 4T1 xenograft model, in vivo photoacoustic imaging confirmed the targeted property of HPB/P4VP-b-PEO NPs due to the enhanced EPR effect. The photoacoustic signal in the tumor at 24 h p.i. was more than ∼10 times that of the pre-injection group. By virtue of their EPR effect, HPB/P4VP-b-PEO NPs achieved a good photothermal therapeutic efficacy in vivo.

Graphical abstract: Heteropoly blue doped polymer nanoparticles: an efficient theranostic agent for targeted photoacoustic imaging and near-infrared photothermal therapy in vivo

Supplementary files

Article information

Article type
Paper
Submitted
11 Oct 2016
Accepted
21 Nov 2016
First published
23 Nov 2016

J. Mater. Chem. B, 2017,5, 382-387

Heteropoly blue doped polymer nanoparticles: an efficient theranostic agent for targeted photoacoustic imaging and near-infrared photothermal therapy in vivo

Y. Yan, Q. Yang, J. Wang, H. Jin, J. Wang, H. Yang, Z. Zhou, Q. Tian and S. Yang, J. Mater. Chem. B, 2017, 5, 382 DOI: 10.1039/C6TB02652D

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