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Issue 6, 2017
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BODIPY-Mn nanoassemblies for accurate MRI and phototherapy of hypoxic cancer

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Abstract

Hypoxia promotes not only the metastasis of tumors but also therapeutic resistance. Photosensitizer-mediated consumption of O2 during photodynamic therapy (PDT) reinforces tumor hypoxia. Herein, a light-dependent attenuator of a hypoxic environment is reported for accurate MRI and phototherapy of hypoxic cancer. First, a photoresponsive Mn(II) nanoassembly was constructed, then it was assembled with bovine serum albumin (BSA) and modified with polyethylene glycol–folic acid (PEG–FA), forming cancer targeting Mn–DBA@BSA–FA nanoassemblies, which offer T1 signals and can catalyze the water oxidation reaction under irradiation of red light emitting diode (LED) light with the generation of O2 and heat. Moreover, they could selectively penetrate through and accumulate in the tumor tissues with clear T1 magnetic resonance imaging (MRI) signals, and have remarkably eliminated the tumors in vivo, while they are of low toxicity to the healthy organs. The release of the Mn(II) complex from the nanoparticles in an acidic environment and the in vivo biodistribution results confirm the selective cancer targeting. Our work demonstrates the potential of nanoparticles as excellent theranostic agents for MR imaging combined with phototherapy triggered by near-infrared light.

Graphical abstract: BODIPY-Mn nanoassemblies for accurate MRI and phototherapy of hypoxic cancer

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Supplementary files

Article information


Submitted
02 Oct 2016
Accepted
09 Jan 2017
First published
11 Jan 2017

J. Mater. Chem. B, 2017,5, 1275-1283
Article type
Paper

BODIPY-Mn nanoassemblies for accurate MRI and phototherapy of hypoxic cancer

W. Lu, Y. Lan, K. Xiao, Q. Xu, L. Qu, Q. Chen, T. Huang, J. Gao and Y. Zhao, J. Mater. Chem. B, 2017, 5, 1275
DOI: 10.1039/C6TB02575G

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