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Issue 48, 2016
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Core–shell alginate@silica microparticles encapsulating probiotics

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Abstract

Lactobacillus rhamnosus GG (LGG) was encapsulated in core–shell alginate–silica microcapsules by coating the electrosprayed ionogel with a silica shell via hydrolysis/condensation of alkoxysilane precursors. The viability of encapsulated LGG highly depends on the mineralisation conditions (in aqueous or organic phases), identified as a critical step. More importantly, due to the unswelling of silica and to its mesoporosity that allows nutriment-metabolite diffusion, it was possible to avoid cell leakage and additionally insure bacterial growth inside the microcapsules. The results of this work gave a proof-of-concept for controlled bacterial proliferation in microcompartments, which have straightforward applications in oral delivery of probiotics.

Graphical abstract: Core–shell alginate@silica microparticles encapsulating probiotics

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Publication details

The article was received on 26 Oct 2016, accepted on 17 Nov 2016 and first published on 17 Nov 2016


Article type: Paper
DOI: 10.1039/C6TB02802K
Citation: J. Mater. Chem. B, 2016,4, 7929-7935

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    Core–shell alginate@silica microparticles encapsulating probiotics

    F. B. Haffner, M. Girardon, S. Fontanay, N. Canilho, R. E. Duval, M. Mierzwa, M. Etienne, R. Diab and A. Pasc, J. Mater. Chem. B, 2016, 4, 7929
    DOI: 10.1039/C6TB02802K

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