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Issue 42, 2016
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Iridium(iii) complexes with 1,10-phenanthroline-based N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection

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Abstract

A systematic study was performed to investigate the relationship between molecular structure and G-quadruplex sensing ability for a series of structurally related cyclometallated iridium(III) complexes. The novel complex 7 was used to construct a label-free luminescent switch-on G-quadruplex-based assay for RNase H activity in buffered solution. The constructed detection platform was simple, low-cost and highly sensitive for RNase H, and functioned effectively in the presence of cellular debris.

Graphical abstract: Iridium(iii) complexes with 1,10-phenanthroline-based N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection

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Supplementary files

Article information


Submitted
07 Sep 2016
Accepted
29 Sep 2016
First published
29 Sep 2016

J. Mater. Chem. B, 2016,4, 6791-6796
Article type
Communication

Iridium(III) complexes with 1,10-phenanthroline-based N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection

L. Lu, W. Wang, C. Yang, T. Kang, C. Leung and D. Ma, J. Mater. Chem. B, 2016, 4, 6791
DOI: 10.1039/C6TB02316A

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