An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2

Anakin C. S. Leung; Engui Zhao; Ryan T. K. Kwok; Jacky W. Y. Lam; Chris W. T. Leung; Haiqin Deng; Ben Zhong Tang

doi:10.1039/C6TB01734G

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An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H₂O₂†

Anakin C. S. Leung,‡^ab Engui Zhao,‡^ab Ryan T. K. Kwok,^ab Jacky W. Y. Lam,^ab Chris W. T. Leung,^ab Haiqin Deng^ab and Ben Zhong Tang*^abc

Author affiliations

* Corresponding authors

^a Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, Division of Biomedical Engineering, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

^b HKUST-Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-tech Park, Nanshan, Shenzhen 518057, China

^c Guangdong Innovative Research Team, SCUT-HKUST Joint Research Laboratory, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology (SCUT), Guangzhou 510640, China

Abstract

A bioprobe, TPE–Zn₂BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H₂O₂. TPE–Zn₂BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.

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Article information

DOI: https://doi.org/10.1039/C6TB01734G
Article type: Communication
Submitted: 11 Jul 2016
Accepted: 26 Jul 2016
First published: 26 Jul 2016

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J. Mater. Chem. B, 2016,4, 5510-5514

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An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H₂O₂

A. C. S. Leung, E. Zhao, R. T. K. Kwok, J. W. Y. Lam, C. W. T. Leung, H. Deng and B. Z. Tang, J. Mater. Chem. B, 2016, 4, 5510 DOI: 10.1039/C6TB01734G

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Journal of Materials Chemistry B