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Issue 44, 2016
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Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions

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Abstract

Herein the optimization of the physicochemical properties and surface biocompatibility of polyelectrolyte multilayers of the natural, biocompatible and biodegradable, linear polysaccharides hyaluronan and chitosan by Hofmeister anions was systematically investigated. We demonstrated that there is an interconnection between the bulk and surface properties of HA/Chi multilayers both varying in accordance with the arrangement of the anions in the Hofmeister series. Kosmotropic anions increased the hydration, thickness, micro- and macro-roughness, and hydrophilicity and improved the biocompatibility of the films by reduction (2 orders of magnitude) of the films stiffness and complete anti-thrombogenicity.

Graphical abstract: Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions

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Article information


Submitted
02 Jul 2016
Accepted
07 Oct 2016
First published
10 Oct 2016

J. Mater. Chem. B, 2016,4, 7092-7100
Article type
Paper

Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions

T. D. Andreeva, H. Hartmann, S. G. Taneva and R. Krastev, J. Mater. Chem. B, 2016, 4, 7092
DOI: 10.1039/C6TB01638C

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