Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 5, 2016
Previous Article Next Article

Hollow ZrO2/PPy nanoplatform for improved drug delivery and real-time CT monitoring in synergistic photothermal-chemo cancer therapy

Author affiliations

Abstract

With the aim of fabricating multifunctional nanoplatforms for cancer diagnosis and therapy, we design hollow ZrO2 nanospheres as novel nanocarriers with enhanced CT imaging properties to integrate NIR light absorbing agents and anti-cancer drugs into one nanosystem. Polypyrrole (PPy) is encapsulated into the hollow ZrO2 nanospheres to endow the nanosystem with strong photothermal transfer capability via an oxidative polymerization method. The anti-cancer drug, doxorubicin (DOX), was loaded into the hollow ZrO2 nanospheres with a high loading content and Dox could be released from the carrier by NIR photothermal stimulus. The hollow ZrO2 nanoplatform has been successfully demonstrated for synergistic photothermal-chemo therapy, both in vitro and in vivo. Due to the excellent X-ray attenuation ability of Zr, the biodistribution of this nanosystem was real-time monitored via CT imaging technology using mini swine as animal models. ICP-OES analysis of tissues obtained from the biopsy also confirms the biodistribution. The in vitro and in vivo toxicity evaluation shows that this nanosystem has good biocompatibility and has great prospects for imaging-guided photothermal-chemo cancer therapy.

Graphical abstract: Hollow ZrO2/PPy nanoplatform for improved drug delivery and real-time CT monitoring in synergistic photothermal-chemo cancer therapy

Back to tab navigation

Supplementary files

Article information


Submitted
22 Oct 2015
Accepted
21 Dec 2015
First published
22 Dec 2015

J. Mater. Chem. B, 2016,4, 859-866
Article type
Paper

Hollow ZrO2/PPy nanoplatform for improved drug delivery and real-time CT monitoring in synergistic photothermal-chemo cancer therapy

L. Tan, T. Liu, C. Fu, S. Wang, S. Fu, J. Ren and X. Meng, J. Mater. Chem. B, 2016, 4, 859
DOI: 10.1039/C5TB02205C

Social activity

Search articles by author

Spotlight

Advertisements