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Issue 5, 2016
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Hollow ZrO2/PPy nanoplatform for improved drug delivery and real-time CT monitoring in synergistic photothermal-chemo cancer therapy

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Abstract

With the aim of fabricating multifunctional nanoplatforms for cancer diagnosis and therapy, we design hollow ZrO2 nanospheres as novel nanocarriers with enhanced CT imaging properties to integrate NIR light absorbing agents and anti-cancer drugs into one nanosystem. Polypyrrole (PPy) is encapsulated into the hollow ZrO2 nanospheres to endow the nanosystem with strong photothermal transfer capability via an oxidative polymerization method. The anti-cancer drug, doxorubicin (DOX), was loaded into the hollow ZrO2 nanospheres with a high loading content and Dox could be released from the carrier by NIR photothermal stimulus. The hollow ZrO2 nanoplatform has been successfully demonstrated for synergistic photothermal-chemo therapy, both in vitro and in vivo. Due to the excellent X-ray attenuation ability of Zr, the biodistribution of this nanosystem was real-time monitored via CT imaging technology using mini swine as animal models. ICP-OES analysis of tissues obtained from the biopsy also confirms the biodistribution. The in vitro and in vivo toxicity evaluation shows that this nanosystem has good biocompatibility and has great prospects for imaging-guided photothermal-chemo cancer therapy.

Graphical abstract: Hollow ZrO2/PPy nanoplatform for improved drug delivery and real-time CT monitoring in synergistic photothermal-chemo cancer therapy

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Publication details

The article was received on 22 Oct 2015, accepted on 21 Dec 2015 and first published on 22 Dec 2015


Article type: Paper
DOI: 10.1039/C5TB02205C
Citation: J. Mater. Chem. B, 2016,4, 859-866

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    Hollow ZrO2/PPy nanoplatform for improved drug delivery and real-time CT monitoring in synergistic photothermal-chemo cancer therapy

    L. Tan, T. Liu, C. Fu, S. Wang, S. Fu, J. Ren and X. Meng, J. Mater. Chem. B, 2016, 4, 859
    DOI: 10.1039/C5TB02205C

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