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Issue 4, 2016
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Antineoplastic busulfan encapsulated in a metal organic framework nanocarrier: first in vivo results

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Abstract

Nanoparticles of a mesoporous iron(III) trimesate MIL-100 nanocarrier encapsulating high amounts of the challenging antineoplastic busulfan were administered to rats and compared with the commercial Busilvex®. Large differences in serum concentration of both busulfan and trimesate revealed the great impact of drug encapsulation both on the drug and on nanoparticle pharmacokinetics during the first 24 h of administration.

Graphical abstract: Antineoplastic busulfan encapsulated in a metal organic framework nanocarrier: first in vivo results

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Publication details

The article was received on 07 Oct 2015, accepted on 17 Dec 2015 and first published on 18 Dec 2015


Article type: Communication
DOI: 10.1039/C5TB02084K
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J. Mater. Chem. B, 2016,4, 585-588

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    Antineoplastic busulfan encapsulated in a metal organic framework nanocarrier: first in vivo results

    M. T. Simon-Yarza, T. Baati, A. Paci, L. L. Lesueur, A. Seck, M. Chiper, R. Gref, C. Serre, P. Couvreur and P. Horcajada, J. Mater. Chem. B, 2016, 4, 585
    DOI: 10.1039/C5TB02084K

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