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Issue 1, 2016
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Cellular modulation by the elasticity of biomaterials

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Abstract

The behaviors and functions of individual cells, fundamental to the complexity of multicellular organisms, are regulated by their integrated response to a variety of environmental cues such as soluble factors, extracellular matrix (ECM)-mediated signals, and cell–cell interactions. Among these cues, the biomechanical feature of the ECM, represented by its elasticity, has been increasingly recognized as a dominating factor of cell fate. This review article aims to provide an overview of the general principles and recent advances in the field of matrix elasticity-dependent regulation of cellular activities and functions, the underlying biomechanical and molecular mechanisms, as well as pathophysiological implications. A discussion is also provided as to how material design strategies can be used to control the local microenvironment of stem cells to direct their lineage commitment and functions toward tissue development and regeneration.

Graphical abstract: Cellular modulation by the elasticity of biomaterials

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Article information


Submitted
06 Oct 2015
Accepted
17 Nov 2015
First published
18 Nov 2015

J. Mater. Chem. B, 2016,4, 9-26
Article type
Review Article
Author version available

Cellular modulation by the elasticity of biomaterials

F. Han, C. Zhu, Q. Guo, H. Yang and B. Li, J. Mater. Chem. B, 2016, 4, 9
DOI: 10.1039/C5TB02077H

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