An integrated nanoplatform for theranostics via multifunctional core–shell ferrite nanocubes

Abstract

Magnetic core–shell ferrite nanocubes (MNCs) were prepared by a two-step pyrolysis. The MNCs not only exhibit an excellent magnetothermal effect, but also can be used as T₂ magnetic resonance (MR) imaging agents. To obtain their good biocompatibility and targeting ability, MNCs were modified with poly(ethylene glycol) (PEG) and hyaluronic acid (HA). To further construct an integrated nanoplatform for theranostics, doxorubicin (DOX) was loaded onto the surface of MNCs by pH and heat sensitive chemical bonding. Notably, the MNCs showed a great stability and magnetothermal effect. Moreover, they showed negligible toxicity and synergistic therapy in vitro. Meanwhile, their MR imaging in vivo was further verified. A novel integrated nanoplatform facilitates excellent targeted MR imaging guided synergism of magnetothermal and chemotherapy. The multifunctional nanocubes will be capable of playing a vital role in future cancer therapy.