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Issue 6, 2016
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Novel biocompatible electrospun gelatin fiber mats with antibiotic drug delivery properties

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Abstract

The aim of this study was to synthesize stable gelatin electrospun mats (ESMs) (cross-linked by glutaraldehyde (GTA) vapors) with tunable drug release properties using pH as a stimulus. Gelatin ESMs loaded with rhodamine as a model drug were first synthesized. The in vitro release of rhodamine was characterized to understand the mechanisms of drug release and the effects of both cross-linker concentration and pH on drug release. An optimal cross-linker concentration of 5% was evidenced to provide ESMs allowing both sustainable release of drugs at pH 7 and burst release at pH 2. The release profiles were then fitted with a power law model to describe the release kinetics. The chlorhexidine antibiotic drug was finally loaded into the optimal electrospun mat and its bactericidal activity was demonstrated against Gram-negative (E. coli) and Gram-positive (S. epidermidis) bacteria by agar diffusion tests. This biocompatible material was shown to efficiently destroy bacterial biofilms and prevent bacterial growth within a short time (3 h), while maintaining its antibacterial activity up to at least 72 h. This study provides a promising material, which could treat infected sites and prevent infections, with tunable drug releasing properties using pH as a stimulus.

Graphical abstract: Novel biocompatible electrospun gelatin fiber mats with antibiotic drug delivery properties

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Supplementary files

Article information


Submitted
11 Sep 2015
Accepted
29 Dec 2015
First published
30 Dec 2015

J. Mater. Chem. B, 2016,4, 1134-1141
Article type
Paper

Novel biocompatible electrospun gelatin fiber mats with antibiotic drug delivery properties

S. Nagarajan, L. Soussan, M. Bechelany, C. Teyssier, V. Cavaillès, C. Pochat-Bohatier, P. Miele, N. Kalkura, J. Janot and S. Balme, J. Mater. Chem. B, 2016, 4, 1134
DOI: 10.1039/C5TB01897H

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