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Issue 9, 2016
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Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy

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Abstract

Host body response to a foreign medical device plays a critical role in defining its fate post implantation. It is thus important to control host–material interactions by designing innovative implant surfaces. In the recent years, biochemical and topographical features have been explored as main target to produce this new type of bioinert or bioresponsive implants. The review discusses specific biofunctional materials and strategies to achieve a precise control over implant surface properties and presents possible solutions to develop next generation of implants, particularly in the fields of bone and cardiovascular therapy.

Graphical abstract: Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy

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Article information


Submitted
17 Aug 2015
Accepted
13 Oct 2015
First published
16 Oct 2015

J. Mater. Chem. B, 2016,4, 1586-1599
Article type
Review Article
Author version available

Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy

S. Pacelli, V. Manoharan, A. Desalvo, N. Lomis, K. S. Jodha, S. Prakash and A. Paul, J. Mater. Chem. B, 2016, 4, 1586
DOI: 10.1039/C5TB01686J

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