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Issue 46, 2015
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Theranostic CuS nanoparticles targeting folate receptors for PET image-guided photothermal therapy

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Abstract

Copper sulfide nanoparticles (CuS NPs) have been reported as a single-compartment theranostic nanosystem to visualize and treat tumors simultaneously. However, few studies have investigated the in vivo tumor-targeted delivery of this class of nanoparticles. In this study, we introduced a tumor-specific targeting ligand, folic acid (FA), onto the surface of CuS NPs as a model system to demonstrate the feasibility of actively targeted CuS NPs for positron emission tomography (PET) imaging and PET image-guided photothermal therapy (PTT). A one-pot synthetic method was used for introducing FA to CuS NPs to yield FA–CuS NPs. Biodistribution studies in mice bearing folate receptor-expressing KB tumor showed a significantly higher tumor uptake of FA–CuS NPs than non-targeted polyethylene glycol (PEG)-coated PEG–CuS NPs after intravenous injection. Moreover, tumor uptake of FA–CuS NPs could be effectively blocked by free FA. Biodistribution and clearance of 64Cu-labeled FA–CuS NPs (FA–[64Cu]CuS NPs) could be readily visualized by microPET (μPET), which confirmed a significantly higher level of tumor uptake of FA–[64Cu]CuS NPs than non-targeted PEG–[64Cu]CuS NPs. μPET image-guided PTT with FA–CuS NPs mediated a substantially greater tumor damage compared with PTT mediated by PEG–CuS NPs. Thus, FA–CuS NPs are promising candidates for PTT of folate receptor-positive tumors.

Graphical abstract: Theranostic CuS nanoparticles targeting folate receptors for PET image-guided photothermal therapy

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Publication details

The article was received on 09 Sep 2015, accepted on 19 Oct 2015 and first published on 22 Oct 2015


Article type: Paper
DOI: 10.1039/C5TB01866H
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J. Mater. Chem. B, 2015,3, 8939-8948

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    Theranostic CuS nanoparticles targeting folate receptors for PET image-guided photothermal therapy

    M. Zhou, S. Song, J. Zhao, M. Tian and C. Li, J. Mater. Chem. B, 2015, 3, 8939
    DOI: 10.1039/C5TB01866H

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