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Issue 44, 2015
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Modulation of the osteoconductive property and immune response of poly(ether ether ketone) by modification with calcium ions

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Abstract

Both bone-forming cells and immune cells have pivotal roles in bone tissue repair. In this work, we prepared a Ca-modified poly(ether ether ketone) (PEEK) to enhance the osteoconductivity but mitigate immune response of cells. To modify Ca ions onto a chemically inert PEEK, PEEK was first coated with poly(norepinephrine) followed by soaking in Ca(OH)2 aqueous solution. Modification of Ca ions onto PEEK enhanced the proliferation and differentiation of MC3T3-E1 preosteoblast cells and human mesenchymal stem cells, but had no apparent effect on MLC-6 osteoclast-like cells. Naïve RAW264.7 macrophages cultured on pristine PEEK produced proinflammatory cytokines, but not on Ca-modified PEEK. Lipopolysaccharide-stimulated RAW264.7 macrophages on Ca-modified PEEK produced lower levels of proinflammatory cytokines but higher levels of anti-inflammatory cytokines compared with those on pristine PEEK. Lower levels of proinflammatory cytokines on Ca-modified PEEK were partially owing to higher interleukin-10 production mediated by Ca-activated pathways. Simple Ca modification of PEEK was shown to activate osteoblastic cell proliferation and differentiation, and shift macrophages towards an anti-inflammatory/wound healing type, which would be useful not only for bone tissue implants but also other implanted biomaterials.

Graphical abstract: Modulation of the osteoconductive property and immune response of poly(ether ether ketone) by modification with calcium ions

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Publication details

The article was received on 17 Aug 2015, accepted on 08 Oct 2015 and first published on 09 Oct 2015


Article type: Paper
DOI: 10.1039/C5TB01679G
J. Mater. Chem. B, 2015,3, 8738-8746

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    Modulation of the osteoconductive property and immune response of poly(ether ether ketone) by modification with calcium ions

    R. Toita, Sunarso, A. N. Rashid, K. Tsuru and K. Ishikawa, J. Mater. Chem. B, 2015, 3, 8738
    DOI: 10.1039/C5TB01679G

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