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Issue 39, 2015
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“Cleaning” the surface of hydroxyapatite nanorods by a reaction-dissolution approach

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Abstract

Synthetic nanoparticles are always terminated with coating molecules, which are often cytotoxic and not desired in biomedicine. Here we propose a novel reaction-dissolution approach to remove the cytotoxic coating molecules. A two-component solution is added to the nanoparticle solution; one component reacts with the coating molecules to form a salt whereas another is a solvent for dissolving and thus removing the salt. As a proof of concept, this work uses a NaOH–ethanol solution to remove the cytotoxic linoleic acid molecules coated on the hydroxyapatite nanorods (HAP-NRs). The removal of the coating molecules not only significantly improves the biocompatibility of HAP-NRs but also enables their oriented attachment into tightly-bound superstructures, which mimic the organized HAP crystals in bone and enamel and can promote the osteogenic differentiation of mesenchymal stem cells. Our reaction-dissolution approach can be extended to the surface “cleaning” of other nanomaterials.

Graphical abstract: “Cleaning” the surface of hydroxyapatite nanorods by a reaction-dissolution approach

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Publication details

The article was received on 27 Jul 2015, accepted on 26 Aug 2015 and first published on 03 Sep 2015


Article type: Paper
DOI: 10.1039/C5TB01509J
J. Mater. Chem. B, 2015,3, 7667-7672

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    “Cleaning” the surface of hydroxyapatite nanorods by a reaction-dissolution approach

    B. Cao, M. Yang, L. Wang, H. Xu, Y. Zhu and C. Mao, J. Mater. Chem. B, 2015, 3, 7667
    DOI: 10.1039/C5TB01509J

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