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Issue 46, 2015
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Design of metal organic framework–enzyme based bioelectrodes as a novel and highly sensitive biosensing platform

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Abstract

Nanocomposites combining the mesoporous iron(III) trimesate MIL-100(Fe) (MIL: Matériaux Institut Lavoisier) and platinum nanoparticles (Pt-NPs) have been used as immobilization matrices of glucose oxidase (GOx). Due to the physico-chemical properties of Pt-NPs (electroactivity) and MIL-100(Fe) (high specific surface area and pore volume, biocompatibility), the resulting GOx–MIL-100(Fe)–PtNP bioelectrode exhibits excellent electrocatalytic performances for glucose detection. This novel glucose biosensor presents a high sensitivity of 71 mA M−1 cm−2 under optimum conditions and a low limit of detection of 5 μM with low response time (<5 s). In contrast, substitution of iron by chromium or aluminum in MIL-100 leads to a much lower sensitivity and higher response time values, suggesting that the iron centres of MIL-100(Fe) may be involved in a synergistic effect which indeed enhances the catalytic oxidation of glucose and biosensor activity. Thus, this work extends the scope of MOF nanoparticles with engineered cores and surface to the field of highly sensitive, durable glucose biosensors.

Graphical abstract: Design of metal organic framework–enzyme based bioelectrodes as a novel and highly sensitive biosensing platform

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Publication details

The article was received on 14 Jul 2015, accepted on 07 Oct 2015 and first published on 08 Oct 2015


Article type: Paper
DOI: 10.1039/C5TB01412C
J. Mater. Chem. B, 2015,3, 8983-8992

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    Design of metal organic framework–enzyme based bioelectrodes as a novel and highly sensitive biosensing platform

    S. Patra, T. Hidalgo Crespo, A. Permyakova, C. Sicard, C. Serre, A. Chaussé, N. Steunou and L. Legrand, J. Mater. Chem. B, 2015, 3, 8983
    DOI: 10.1039/C5TB01412C

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