Issue 42, 2015

Zwitterionic amphiphile coated magnetofluorescent nanoparticles – synthesis, characterization and tumor cell targeting

Abstract

Magnetofluorescent nanoparticles (MFNPs) have recently attracted significant research interests due to their potential application in biological manipulation and imaging. In this work, through a simple and fast self-assembling process, we first report the preparation of zwitterionic MFNPs (ZW-MFNPs) in the form of micelles using our newly synthesized zwitterionic amphiphiles, CuInS2/ZnS quantum dots, and MnFe2O4 magnetic nanoparticles. ZW-MFNPs integrate both MnFe2O4 magnetic nanoparticles and CuInS2/ZnS quantum dots in their hydrophobic cores and zwitterionic groups such as carboxybetaine and sulfobetaine on their hydrophilic shells. ZW-MFNPs possess dual imaging properties, high (Mn + Fe) recovery, excellent stability in aqueous solutions with a wide pH/ionic-strength range and physiological media, minimal cytotoxicity, and specific targeting to brain tumor cells after bioconjugation with chlorotoxin. The unique characteristics of ZW-MFNPs may open an avenue for these particles to be employed in broad biomedical applications.

Graphical abstract: Zwitterionic amphiphile coated magnetofluorescent nanoparticles – synthesis, characterization and tumor cell targeting

Supplementary files

Article information

Article type
Paper
Submitted
10 Jun 2015
Accepted
14 Sep 2015
First published
14 Sep 2015

J. Mater. Chem. B, 2015,3, 8328-8336

Author version available

Zwitterionic amphiphile coated magnetofluorescent nanoparticles – synthesis, characterization and tumor cell targeting

V. G. Demillo and X. Zhu, J. Mater. Chem. B, 2015, 3, 8328 DOI: 10.1039/C5TB01116G

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