Jump to main content
Jump to site search

Issue 39, 2015
Previous Article Next Article

Evaluation of AgHAP-containing polyurethane foam dressing for wound healing: synthesis, characterization, in vitro and in vivo studies

Author affiliations

Abstract

Silver-containing dressings have been widely used to control wound infection. In this study, we developed various amounts of silver-hydroxyapatite (AgHAP)-containing polyurethane foams (PUFs) (AgHAP–PUFs), and their biological properties including biocompatibility, antibacterial activities, and in vivo wound healing properties were evaluated in the Sprague-Dawley rat model. From electron microscopy imaging, it was found that AgHAP particles are uniformly dispersed inside PUFs. The release of Ag from PUFs was dependent on both time and concentration, i.e., the amount of released Ag was significantly higher with increasing immersion time and Ag content in the PUFs. From the cytotoxicity test, AgHAP–PUFs exhibited high antibacterial efficacy against four pathogenic bacteria, and they were not cytotoxic against L-929 fibroblast cells. AgHAP–PUF treated groups exhibited scar-free wound healing by promoting re-epithelialization and collagen deposition in the infected excision wound model. Overall, it is evident that AgHAP–PUFs may be considered as a good antibacterial wound dressing for infected wounds due to their good antibacterial activity, biocompatibility, and wound healing rate.

Graphical abstract: Evaluation of AgHAP-containing polyurethane foam dressing for wound healing: synthesis, characterization, in vitro and in vivo studies

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 May 2015, accepted on 17 Aug 2015 and first published on 27 Aug 2015


Article type: Paper
DOI: 10.1039/C5TB00995B
J. Mater. Chem. B, 2015,3, 7752-7763

  •   Request permissions

    Evaluation of AgHAP-containing polyurethane foam dressing for wound healing: synthesis, characterization, in vitro and in vivo studies

    D. G. Pyun, H. S. Yoon, H. Y. Chung, H. J. Choi, T. Thambi, B. S. Kim and D. S. Lee, J. Mater. Chem. B, 2015, 3, 7752
    DOI: 10.1039/C5TB00995B

Search articles by author

Spotlight

Advertisements