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Issue 18, 2015
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Biodegradable PLGA nanoparticles loaded with hydrophobic drugs: confocal Raman microspectroscopic characterization

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Abstract

Poly(lactic-co-glycolic acid) (PLGA) nanoparticles with bicyclol (5%) and 3-n-butyl-6-bromophthalid (Br-NBP) (3%) were prepared by an emulsification–solvent evaporation technique. The PLGA nanoparticles were, for the first time, successfully characterized by a laser trapping/confocal Raman spectroscopic technique using only individual PLGA nanoparticles. This technique allowed us to selectively obtain Raman spectra of optically trapped PLGA nanoparticles (∼10 nanoparticles) in solution. The Raman spectra of the PLGA nanoparticles loaded with hydrophobic drugs showed that these drugs were incorporated in the nanoparticles.

Graphical abstract: Biodegradable PLGA nanoparticles loaded with hydrophobic drugs: confocal Raman microspectroscopic characterization

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Publication details

The article was received on 09 Mar 2015, accepted on 09 Apr 2015 and first published on 10 Apr 2015


Article type: Communication
DOI: 10.1039/C5TB00434A
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J. Mater. Chem. B, 2015,3, 3677-3680

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    Biodegradable PLGA nanoparticles loaded with hydrophobic drugs: confocal Raman microspectroscopic characterization

    H. Yan, Y. Hou, P. Niu, K. Zhang, T. Shoji, Y. Tsuboi, F. Yao, L. Zhao and J. Chang, J. Mater. Chem. B, 2015, 3, 3677
    DOI: 10.1039/C5TB00434A

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