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Issue 9, 2015
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Core–shell microspheres delivering FGF-2 and BMP-2 in different release patterns for bone regeneration

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Abstract

Bone regeneration by applying fibroblast growth factor-2 (FGF-2) plus bone morphogenetic protein-2 (BMP-2) is considered advantageous over a single growth factor (GF) treatment because the spontaneous repair of bone defects is essentially regulated by a series of GFs, including FGF-2 and BMP-2. However, the temporal interactions between FGF-2 and BMP-2 remain elusive and how to take full advantage of the interactions is a bottleneck in translating this dual-GF strategy into clinical applications. To compare the long-term effects of different temporal patterns of FGF-2 and BMP-2 on bone regeneration, a novel delivery system is needed. Herein, we report a type of PLLA core–PLGA shell double-walled microsphere. Different release patterns of FGF-2 and BMP-2 in the core and shell, respectively, were achieved due to different distributions of these two GFs. In vivo evaluations of different release patterns of dual GFs using a rat bone graft model suggested that a sequential delivery of FGF-2 and BMP-2 helped bridge and remodel the critical-sized bone grafts more efficiently than the other release patterns. More importantly, core–shell microspheres simultaneously and continuously releasing FGF-2 and BMP-2 resulted in the obvious resorption of grafted bone and bone non-union at 4 weeks. Consistently, the in vitro treatment of bovine bone sections by FGF-2 plus BMP-2 led to enhanced osteoclastogenesis compared to single GF treatments. The temporal organization of FGF-2 and BMP-2 by taking advantage of the core–shell microspheres will enable the development of more efficient devices for bone defects than existing delivery systems.

Graphical abstract: Core–shell microspheres delivering FGF-2 and BMP-2 in different release patterns for bone regeneration

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Publication details

The article was received on 13 Nov 2014, accepted on 12 Jan 2015 and first published on 13 Jan 2015


Article type: Paper
DOI: 10.1039/C4TB01876A
J. Mater. Chem. B, 2015,3, 1907-1920

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    Core–shell microspheres delivering FGF-2 and BMP-2 in different release patterns for bone regeneration

    S. Wang, W. Ju, P. Shang, L. Lei and H. Nie, J. Mater. Chem. B, 2015, 3, 1907
    DOI: 10.1039/C4TB01876A

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