Issue 15, 2015
From the journal:

Journal of Materials Chemistry B

In vivo multi-photon luminescence imaging of cerebral vasculature and blood–brain barrier integrity using gold nanoparticles†

Hwan-Jun Yoon,‡ab   Eek-Sung Lee,‡bc   Minseok Kang,ab   Yong Jeong*abc  and  Ji-Ho Park*abc  

* Corresponding authors

a Department of Bio and Brain Engineering, KAIST, Daejeon, South Korea
E-mail: jihopark@kaist.ac.kr, yong@kaist.ac.kr
Fax: +82-42-350-4310
Tel: +82-42-350-4330

b KAIST Institute for Optical Science and Technology, KAIST, Daejeon, South Korea

c Graduate School of Medical Science and Engineering, KAIST, Daejeon, South Korea

Abstract

We report that time-dependent morphological changes of cortical vasculature, which would be associated with blood–brain barrier disruption, can be clearly visualized with high spatial resolution in a stroke mouse model using the multi-photon luminescence of long-circulating gold nanoparticles.

Graphical abstract: In vivo multi-photon luminescence imaging of cerebral vasculature and blood–brain barrier integrity using gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/C4TB01759E
Article type
Communication
Submitted
23 Oct 2014
Accepted
05 Mar 2015
First published
09 Mar 2015

J. Mater. Chem. B, 2015,3, 2935-2938

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In vivo multi-photon luminescence imaging of cerebral vasculature and blood–brain barrier integrity using gold nanoparticles

H. Yoon, E. Lee, M. Kang, Y. Jeong and J. Park, J. Mater. Chem. B, 2015, 3, 2935 DOI: 10.1039/C4TB01759E

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