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Issue 37, 2014
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Tuning the composition of biocompatible Gd nanohydrogels to achieve hypersensitive dual T1/T2 MRI contrast agents

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Abstract

A series of hydrogel nanoparticles incorporating MRI contrast agents (GdDOTP and MS325) as potential cross-linkers were elaborated by an easy and robust ionotropic gelation process. By this process, high Gd loadings were obtained (between 1.8 and 14.5 × 104 Gd centres per NP). By tuning the cross-linker ionization degree and the nature of the polymer matrix it was possible to boost the r1 relaxivity per Gd centre up to 22-fold. The greatest gains in relaxivity were observed for nanogels for which the polymer matrix was constituted of chitosan and hyaluronan. Relaxivities per Gd centre as high as 100 s−1 mM−1 at 30 MHz can be reached, which highlighted the fact that molecular motion of the Gd chelate was effectively restricted and water access to the inner core of these nanogels was not limited.

Graphical abstract: Tuning the composition of biocompatible Gd nanohydrogels to achieve hypersensitive dual T1/T2 MRI contrast agents

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Publication details

The article was received on 14 May 2014, accepted on 18 Jul 2014 and first published on 25 Jul 2014


Article type: Paper
DOI: 10.1039/C4TB00783B
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Citation: J. Mater. Chem. B, 2014,2, 6397-6405

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    Tuning the composition of biocompatible Gd nanohydrogels to achieve hypersensitive dual T1/T2 MRI contrast agents

    M. Callewaert, V. G. Roullin, C. Cadiou, E. Millart, L. Van Gulik, M. C. Andry, C. Portefaix, C. Hoeffel, S. Laurent, L. V. Elst, R. Muller, M. Molinari and F. Chuburu, J. Mater. Chem. B, 2014, 2, 6397
    DOI: 10.1039/C4TB00783B

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