Jump to main content
Jump to site search

Issue 34, 2014
Previous Article Next Article

A novel zwitterionic bioceramic with dual antibacterial capability

Author affiliations


A novel zwitterionic SBA-15 type bioceramic with dual antibacterial capability has been synthesized. The co-condensation route has been employed to functionalize SBA-15 with primary and secondary amine groups. The resulting material exhibits textural and nanostructural properties comparable to those of pure silica SBA-15, as confirmed by XRD, HR-TEM and N2 adsorption porosimetry. The presence of –NH3/–SiO and >NH2/–SiOzwitterionic pairs on the material surface is evidenced by FTIR and 1H → 13C CP/MAS solid state NMR. The homogeneous distribution of this zwitterionic pairs agrees with the results derived from STEM-EDS studies. ζ-Potential measurements indicate that the zwitterionic nature of this material is preserved at the physiological pH of 7.4. In vitro bacterial assays using S. aureus demonstrate that the zwitterionic material is capable of inhibiting 99.9% of the bacterial adhesion compared to pure silica SBA-15. Moreover, cephalexin loading and delivery assays indicate that the zwitterionic sample is capable of releasing antibiotic molecules over long time periods. This dual antibacterial capability, i.e. antibiofouling and bactericidal, opens up promising expectations for the treatment of bone implant infections.

Graphical abstract: A novel zwitterionic bioceramic with dual antibacterial capability

Back to tab navigation

Supplementary files

Article information

30 Apr 2014
17 Jun 2014
First published
18 Jun 2014

J. Mater. Chem. B, 2014,2, 5639-5651
Article type
Author version available

A novel zwitterionic bioceramic with dual antibacterial capability

M. Colilla, M. Martínez-Carmona, S. Sánchez-Salcedo, M. L. Ruiz-González, J. M. González-Calbet and M. Vallet-Regí, J. Mater. Chem. B, 2014, 2, 5639
DOI: 10.1039/C4TB00690A

Social activity

Search articles by author