Jump to main content
Jump to site search

Issue 31, 2014
Previous Article Next Article

Water-soluble inclusion complex of fullerene with γ-cyclodextrin polymer for photodynamic therapy

Author affiliations

Abstract

A stable aqueous inclusion complex of fullerene (C60) with macromolecules (C60 concentration as high as 3 × 10−4 mol L−1) was achieved by a one-step strategy using γ-cyclodextrin polymer (γ-CDP). The inclusion complex of C60 with γ-CDP (C60–γ-CDP) was characterized by ultraviolet-visible, Raman and 1H-NMR spectroscopies, powder X-ray diffraction analysis, and thermogravimetric analysis. The supramolecular interactions and the equilibrium constant for a 1 : 2 (C60 : CD unit in γ-CDP) complex of C60 with γ-CDP were studied. Under ultraviolet A (UVA) irradiation C60–γ-CDP in water could generate singlet oxygen, which was detected by electron paramagnetic resonance spectroscopy. We also evaluated the cytotoxicities of C60–γ-CDP, and investigated the phototoxicity of C60–γ-CDP and pristine C60 toward B16-F10 melanoma cells. The cell viability test showed that C60–γ-CDP had a significantly higher photodynamic ability than that of the pristine C60 under UVA irradiation. This work demonstrated both a CDP-functionalized strategy for enhancing the water-solubility and phototoxicity of fullerenes for applications in cancer photodynamic therapy, as well as remediating the negative biological effects of pristine fullerenes.

Graphical abstract: Water-soluble inclusion complex of fullerene with γ-cyclodextrin polymer for photodynamic therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Apr 2014, accepted on 21 May 2014 and first published on 21 May 2014


Article type: Paper
DOI: 10.1039/C4TB00560K
Author version
available:
Download author version (PDF)
J. Mater. Chem. B, 2014,2, 5107-5115

  •   Request permissions

    Water-soluble inclusion complex of fullerene with γ-cyclodextrin polymer for photodynamic therapy

    W. Zhang, X. Gong, C. Liu, Y. Piao, Y. Sun and G. Diao, J. Mater. Chem. B, 2014, 2, 5107
    DOI: 10.1039/C4TB00560K

Search articles by author

Spotlight

Advertisements