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Issue 25, 2014
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Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye

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Abstract

Elevated levels of homocysteine (Hcy) in blood are indicative of many high risk cardiovascular and neurodegenerative diseases. Thus, development of highly efficient and selective dyes for monitoring Hcy levels has attracted much attention. This paper reports the utilization of TPE-Cy, an aggregation-induced-emission active hemicyanine dye, as a probe for the detection of Hcy. More interestingly, this dye shows high selectivity to Hcy over cysteine, glutathione and other amino acids in weakly basic buffer solution.

Graphical abstract: Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye

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Supplementary files

Article information


Submitted
08 Apr 2014
Accepted
29 Apr 2014
First published
29 Apr 2014

J. Mater. Chem. B, 2014,2, 3919-3923
Article type
Paper
Author version available

Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye

S. Chen, Y. Hong, J. Liu, N. Tseng, Y. Liu, E. Zhao, J. W. Yip Lam and B. Z. Tang, J. Mater. Chem. B, 2014, 2, 3919
DOI: 10.1039/C4TB00551A

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