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Issue 20, 2014
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Highly water-soluble perylenediimide-cored poly(amido amine) vector for efficient gene transfection

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Abstract

A highly water-soluble perylenediimide-core poly(amido amine) (PDI-PAmAm) with peripheral amine groups has been synthesized. The central PDI chromophore allows optical monitoring of relevant cellular experiments by fluorescence microscopy. The PAmAm shell provides the steric bulk that notably suppresses the aggregation of the central PDI chromophore in aqueous solution. The peripheral amines provide water solubility and positive charges, and also serve as active sites for the further growth of PAmAm. PDI-PAmAm can be rapidly internalized into live cells with high efficacy of gene delivery and low cytotoxicity. Both in vitro and in vivo experiments demonstrate the high gene transfection efficacy of PDI-PAmAm.

Graphical abstract: Highly water-soluble perylenediimide-cored poly(amido amine) vector for efficient gene transfection

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Supplementary files

Article information


Submitted
06 Feb 2014
Accepted
24 Feb 2014
First published
25 Feb 2014

J. Mater. Chem. B, 2014,2, 3079-3086
Article type
Paper
Author version available

Highly water-soluble perylenediimide-cored poly(amido amine) vector for efficient gene transfection

Z. Xu, B. He, W. Wei, K. Liu, M. Yin, W. Yang and J. Shen, J. Mater. Chem. B, 2014, 2, 3079
DOI: 10.1039/C4TB00195H

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