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Issue 25, 2014
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Controllable drug release and effective intracellular accumulation highlighted by anisotropic biodegradable PLGE nanoparticles

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Abstract

Control of the stretching or compressing ratio of spherical nanoparticles (NPs) leads to a dramatic change in the shape and size of particles based on amphiphilic biodegradable poly(lactide-co-glycolide-b-ethylene glycol-b-lactide-co-glycolide) (PLGE) triblock copolymers. Drug release, endocytosis and intracellular accumulation tests on these anisotropic PLGE NPs show significantly enhanced properties in comparison with spherical NPs, indicating they are good candidates for drug delivery.

Graphical abstract: Controllable drug release and effective intracellular accumulation highlighted by anisotropic biodegradable PLGE nanoparticles

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Supplementary files

Article information


Submitted
05 Dec 2013
Accepted
26 Mar 2014
First published
27 Mar 2014

J. Mater. Chem. B, 2014,2, 3911-3914
Article type
Communication
Author version available

Controllable drug release and effective intracellular accumulation highlighted by anisotropic biodegradable PLGE nanoparticles

J. Fan, Y. Song, H. Li, J. Jia, X. Guo and L. Jiang, J. Mater. Chem. B, 2014, 2, 3911
DOI: 10.1039/C3TB21726D

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