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Issue 11, 2014
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Design of peptide-based bolaamphiphiles exhibiting heat-set hydrogelation via retro-Diels–Alder reaction

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Abstract

Supramolecular hydrogels have attracted much attention as smart soft materials. To install various stimuli-responsive functions in the supramolecular hydrogels, skilful utility of chemical reactions for triggering the change in molecular structure of hydrogelators or their precursor in response to external stimuli is a promising strategy. We have recently developed a unique heat-set supramolecular hydrogel, which was triggered by rationally designed molecular conversion of a glycolipid-based bolaamphiphile into a hydrogelator via retro-Diels–Alder reaction. Here we designed new bolaamphiphiles based on short peptide-based hydrogelators as a scaffold to accelerate the heat-set hydrogelation process and also demonstrated the flexible molecular design of such bolaamphiphiles.

Graphical abstract: Design of peptide-based bolaamphiphiles exhibiting heat-set hydrogelation via retro-Diels–Alder reaction

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Supplementary files

Article information


Submitted
28 Nov 2013
Accepted
17 Dec 2013
First published
22 Jan 2014

J. Mater. Chem. B, 2014,2, 1464-1469
Article type
Paper

Design of peptide-based bolaamphiphiles exhibiting heat-set hydrogelation via retro-Diels–Alder reaction

R. Ochi, T. Nishida, M. Ikeda and I. Hamachi, J. Mater. Chem. B, 2014, 2, 1464
DOI: 10.1039/C3TB21680B

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