Jump to main content
Jump to site search

Issue 16, 2014
Previous Article Next Article

Highly ordered and tunable polyHIPEs by using microfluidics

Author affiliations

Abstract

We demonstrate how to generate highly ordered porous matrices from dextran-methacrylate (DEX-MA) using microfluidics. We use a flow focusing device to inject an aqueous solution of DEX-MA and surfactant to break the flow of an organic solvent (cyclohexane) into monodisperse droplets at a high volume fraction (above 74% v/v) to form an ordered high internal phase emulsion (HIPE). We collect the crystalline HIPE structure and freeze it by gelling. The resulting polyHIPEs are characterized by an interconnected and ordered morphology. The size of pores and interconnects ranges between hundreds and tens of micrometers, respectively. The technique that we describe allows for precise tuning of all the structural parameters of the matrices, including their porosity, the size of the pores and the lumen of interconnects between the pores. The resulting ordered and precisely tailored HIPE gels represent a new class of scaffolds for applications in tissue engineering.

Graphical abstract: Highly ordered and tunable polyHIPEs by using microfluidics

Back to tab navigation

Supplementary files

Article information


Submitted
04 Sep 2013
Accepted
31 Jan 2014
First published
03 Feb 2014

This article is Open Access

J. Mater. Chem. B, 2014,2, 2290-2300
Article type
Paper

Highly ordered and tunable polyHIPEs by using microfluidics

M. Costantini, C. Colosi, J. Guzowski, A. Barbetta, J. Jaroszewicz, W. Święszkowski, M. Dentini and P. Garstecki, J. Mater. Chem. B, 2014, 2, 2290
DOI: 10.1039/C3TB21227K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements