Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 4, 2014
Previous Article Next Article

Monodispersed grafted conjugated polyelectrolyte-stabilized magnetic nanoparticles as multifunctional platform for cellular imaging and drug delivery

Author affiliations

Abstract

An anionic grafted conjugated polyelectrolyte was synthesized, and then magnetic nanoparticles stabilized with this material were successfully prepared by a convenient method and used for bioimaging and drug delivery. Grafted conjugated polymer (PFPAA) containing abundant carboxyl groups was attached to the surface of Fe3O4 nanoparticles through ligand exchange with oleic acid and anionic grafted conjugated polyelectrolyte-stabilized magnetic nanoparticles (MNPs@PFPANa) were then obtained by ionization with sodium carbonate. These as-synthesized nanoparticles showed good water solubility and stability, with no precipitation observed in 8 months, and had a narrow size distribution with a mean hydrodynamic diameter of 26 ± 2.4 nm. In addition, these nanoparticles exhibited superparamagnetic properties with a saturation magnetization (Ms) of 20 emu g−1, which sufficient for bioapplications. Upon 48 h incubation with macrophage cells, the obtained nanoparticles showed good biocompatibility of 2 pg Fe per cell as measured by ICP-OES. Furthermore, MNPs@PFPANa were low toxicity as confirmed by an MTT assay using NIH-3T3 fibroblasts. Confocal microscopy results revealed that MNPs@PFPANa can be retained in cytoplasm with high fluorescence. MNPs@PFPANa exhibited good DOX drug loading efficiency of about 10 wt% and showed good therapeutic efficiency for BGC-823 cancer cells. These results indicated such multifunctional nanoparticles would be useful in bioimaging and as drug carriers for cancer treatment.

Graphical abstract: Monodispersed grafted conjugated polyelectrolyte-stabilized magnetic nanoparticles as multifunctional platform for cellular imaging and drug delivery

Back to tab navigation

Article information


Submitted
08 Jul 2013
Accepted
27 Oct 2013
First published
29 Oct 2013

J. Mater. Chem. B, 2014,2, 376-386
Article type
Paper

Monodispersed grafted conjugated polyelectrolyte-stabilized magnetic nanoparticles as multifunctional platform for cellular imaging and drug delivery

X. Lu, R. Jiang, M. Yang, Q. Fan, W. Hu, L. Zhang, Z. Yang, W. Deng, Q. Shen, Y. Huang, X. Liu and W. Huang, J. Mater. Chem. B, 2014, 2, 376
DOI: 10.1039/C3TB20955E

Social activity

Search articles by author

Spotlight

Advertisements