Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 47, 2013
Previous Article Next Article

Towards smart polymeric drug carriers: self-assembling γ-substituted polycaprolactones with highly tunable thermoresponsive behavior

Author affiliations

Abstract

Synthesis and ring opening polymerization of a new γ-substituted ε-caprolactone monomer, γ-(2-methoxyethoxy)-ε-caprolactone is reported. Amphiphilic diblock copolymers comprised of poly[γ-(2-methoxyethoxy)-ε-caprolactone] and thermosensitive poly{γ-2-[2-(2-methoxyethoxy)ethoxy]ethoxy-ε-caprolactone} as the hydrophobic and hydrophilic blocks, respectively, were prepared. The copolymers exhibited fully biodegradable backbones and highly tunable thermoresponsive behavior in the range of 31–43 °C. Additionally, the copolymers were shown to self-assemble in aqueous media above their respective critical micelle concentrations, on the order of 10−2 g L−1. Due to their thermosensitive, self-assembling, and biodegradable properties, these copolymers demonstrate potential for the use in polymeric micellar drug delivery systems.

Graphical abstract: Towards smart polymeric drug carriers: self-assembling γ-substituted polycaprolactones with highly tunable thermoresponsive behavior

Back to tab navigation

Supplementary files

Article information


Submitted
22 Oct 2013
Accepted
27 Oct 2013
First published
29 Oct 2013

J. Mater. Chem. B, 2013,1, 6532-6537
Article type
Paper

Towards smart polymeric drug carriers: self-assembling γ-substituted polycaprolactones with highly tunable thermoresponsive behavior

E. A. Rainbolt, K. E. Washington, M. C. Biewer and M. C. Stefan, J. Mater. Chem. B, 2013, 1, 6532
DOI: 10.1039/C3TB21488E

Social activity

Search articles by author

Spotlight

Advertisements