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Issue 48, 2013
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Improving cellular adhesion on scaffolds for transplantation: synthesising a poly(MMA-co-PEGM) network

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Abstract

Electrospun fibrous matrices prepared from methacrylate-based copolymers are investigated as a tool for retinal pigment epithelium (RPE) transplantation in the treatment of degenerative retinal diseases. Human RPE cells were used to probe the cell–surface interactions on these copolymer matrices. For the first time, simple changes in chemical functionality have been found to induce gel formation of these methacrylate backbone copolymers in vitro. This effect is shown to significantly improve RPE cell adhesion and survival.

Graphical abstract: Improving cellular adhesion on scaffolds for transplantation: synthesising a poly(MMA-co-PEGM) network

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Supplementary files

Article information


Submitted
10 Sep 2013
Accepted
24 Oct 2013
First published
29 Oct 2013

J. Mater. Chem. B, 2013,1, 6627-6633
Article type
Paper

Improving cellular adhesion on scaffolds for transplantation: synthesising a poly(MMA-co-PEGM) network

D. W. Pitt, A. J. Treharne, H. A. Thomson, J. A. Scott, A. J. Lotery and M. C. Grossel, J. Mater. Chem. B, 2013, 1, 6627
DOI: 10.1039/C3TB21248C

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