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Issue 42, 2013
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Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging

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Abstract

Graphene oxide (GO) has many exciting advantages such as easy preparation, low toxicity, good solubility and stability in aqueous solution. However, GO itself has a low near-infrared (NIR) absorption, and thus is not suitable for photothermal therapy and photoacoustic imaging. To overcome this limitation, a novel dye-enhanced GO is prepared utilizing the π–π stacking interactions between GO and indocyanine green (ICG). The ICG–GO complex has a high optical absorbance in the NIR region and exhibits excellent photothermal properties under NIR irradiation. In order to improve the cancer-targeting activity, GO was modified with folic acid (FA). In vitro experiments showed that the ICG–GO–FA nanocomposite could be used for targeted photothermal cancer cell destruction. Moreover, the application of the ICG–GO–FA nanocomposite for photoacoustic imaging was also demonstrated.

Graphical abstract: Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging

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Supplementary files

Article information


Submitted
17 Jul 2013
Accepted
09 Sep 2013
First published
10 Sep 2013

J. Mater. Chem. B, 2013,1, 5762-5767
Article type
Paper

Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging

Y. Wang, Y. Fu, Q. Peng, S. Guo, G. Liu, J. Li, H. Yang and G. Chen, J. Mater. Chem. B, 2013, 1, 5762
DOI: 10.1039/C3TB20986E

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