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Issue 35, 2013
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A highly efficient rare earth metaloxidenanorods based platform for aflatoxin detection

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Abstract

The nanostructured rare earth metal oxide (samarium oxide, n-Sm2O3) nanorods, prepared using a forced hydrolysis technique, have been electrophoretically deposited (EPD) onto an indium-tin-oxide (ITO) glass substrate. This novel platform has been utilized for co-immobilization of monoclonal antibodies of aflatoxin B1 (Ab-AFB1) and bovine serum albumin (BSA) via electrostatic interactions for food toxin (AFB1) detection. Thus prepared n-Sm2O3 nanorods have been characterized by X-ray diffraction (XRD), atomic force microscopy (AFM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectroscopic techniques. The results of electrochemical response studies of the BSA/Ab-AFB1/n-Sm2O3/ITO immunoelectrode obtained as a function of aflatoxin concentration reveal a linearity of 10–700 pg mL−1, a detection limit of 57.82 pg mL−1 cm−2, a response time of 5 s and a sensitivity of 48.39 μA pg−1 mL−1 cm−2 with a regression coefficient of 0.961. The association constant (Ka) for antigen–antibody interactions obtained is 47.9 pg mL−1, which indicates high affinity of antibodies towards the antigen (AFB1). The application of n-Sm2O3 modified electrode for immunosensor analysis offers a novel platform and efficient strategy for the application of rare earth metal oxide materials in bioelectronics.

Graphical abstract: A highly efficient rare earth metal oxide nanorods based platform for aflatoxin detection

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Supplementary files

Article information


Submitted
15 May 2013
Accepted
02 Jul 2013
First published
03 Jul 2013

J. Mater. Chem. B, 2013,1, 4493-4503
Article type
Paper

A highly efficient rare earth metal oxide nanorods based platform for aflatoxin detection

J. Singh, A. Roychoudhury, M. Srivastava, P. R. Solanki, D. W. Lee, S. H. Lee and B. D. Malhotra, J. Mater. Chem. B, 2013, 1, 4493
DOI: 10.1039/C3TB20690D

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