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Issue 39, 2013
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Lipidoligonucleotide conjugates as responsive nanomaterials for drug delivery

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Abstract

We report Lipid OligoNucleotide conjugates (LONs) bearing either two or three hydrophobic chains. LONs self-assemble into micellar aggregates, which provide a suitable reservoir for hydrophobic drugs such as paclitaxel. Our results demonstrate that the composition of the LONs both in terms of the lipid and the oligonucleotide sequence impacts their ability to host lipophilic molecules. Interestingly, binding of the complementary oligonucleotide selectively induces the release of part of the drug payload of the aggregates. These LON based micelles, which efficiently host hydrophobic drugs, represent an original stimuli-responsive drug delivery system.

Graphical abstract: Lipid oligonucleotide conjugates as responsive nanomaterials for drug delivery

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Supplementary files

Article information


Submitted
14 Mar 2013
Accepted
26 Apr 2013
First published
26 Apr 2013

J. Mater. Chem. B, 2013,1, 5329-5334
Article type
Paper

Lipid oligonucleotide conjugates as responsive nanomaterials for drug delivery

O. Pokholenko, A. Gissot, B. Vialet, K. Bathany, A. Thiéry and P. Barthélémy, J. Mater. Chem. B, 2013, 1, 5329
DOI: 10.1039/C3TB20357C

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