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Issue 17, 2013
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Functionalization of dendritic polyethylene with cationic poly(p-phenylene ethynylene) enables efficient siRNA delivery for gene silencing

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Abstract

A novel system based on a dendritic polyethylene–cationic poly(p-phenylene ethynylene) polyvalent nanocarrier was developed for siRNA delivery. By using the combination of a molecular wire and a “dendritic effects” strategy, this design provides the nanocarrier system with low cytotoxicity, cellular imaging and high siRNA delivery efficiency, allowing it to exhibit remarkable gene knockdown abilities as well as real-time monitoring of the siRNA delivery process.

Graphical abstract: Functionalization of dendritic polyethylene with cationic poly(p-phenylene ethynylene) enables efficient siRNA delivery for gene silencing

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Article information


Submitted
03 Dec 2012
Accepted
21 Feb 2013
First published
21 Feb 2013

J. Mater. Chem. B, 2013,1, 2245-2251
Article type
Paper

Functionalization of dendritic polyethylene with cationic poly(p-phenylene ethynylene) enables efficient siRNA delivery for gene silencing

L. Zhang, Q. Yin, J. Li, H. Huang, Q. Wu and Z. Mao, J. Mater. Chem. B, 2013, 1, 2245
DOI: 10.1039/C3TB00480E

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