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Issue 9, 2013
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Preparation of aqueous sol–gel silica and titania multi-layered thin films and their evaluation as biomolecular encapsulation hosts

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Abstract

Multi-layered silica and titania thin films were prepared via an aqueous sol–gel route. The titania layers could efficiently entrap anti-HRP antibodies and showed increase in stability upon ageing, up to 2 months. Specific activity of the entrapped antibodies could be monitored in a reliable manner over one week. The silica films showed lower performances, as a probable consequence of large pore size. Increase in the titania precursor (TiBALDH) concentration and addition of glycerol allowed the design of tri-enzymatic multi-layered systems for the detection of lactose. The multilayer approach showed higher robustness than the co-immobilization of the enzymes in a single layer. This process is simple, solvent-free and flexible, opening the route to multi-biofunctional materials at the nanoscale.

Graphical abstract: Preparation of aqueous sol–gel silica and titania multi-layered thin films and their evaluation as biomolecular encapsulation hosts

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Supplementary files

Article information


Submitted
15 Nov 2012
Accepted
10 Dec 2012
First published
13 Dec 2012

J. Mater. Chem. B, 2013,1, 1235-1240
Article type
Paper

Preparation of aqueous sol–gel silica and titania multi-layered thin films and their evaluation as biomolecular encapsulation hosts

T. Moreau, C. Depagne, G. Suissa, H. Gouzi and T. Coradin, J. Mater. Chem. B, 2013, 1, 1235
DOI: 10.1039/C2TB00417H

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