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Issue 6, 2013
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Biomimetic mineralization of calcium carbonate mediated by a polypeptide-based copolymer

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Abstract

A novel copolymer, β-cyclodextrin-b-poly(L-glutamic acid) (β-CD-b-PLGA), was synthesized by ring-opening polymerization and subsequent hydrolysis reaction. The β-CD-b-PLGA copolymer possesses an oligosaccharide β-CD segment and a polypeptide PLGA segment, with chemical structure resembling natural glycoprotein. The copolymers were applied in regulating the crystallization of calcium carbonate. The effects of the concentration of copolymers and calcium ions were systemically investigated. Various morphologies, including rhombohedra, rod, pseudo-dodecahedra and rosette-like structures, were obtained by adjusting the polymer and Ca2+ concentrations of the initial solution. Investigation of the pseudo-dodecahedra growth mechanism indicates that the copolymers mediate amorphous calcium carbonate formation initially, and then regulate the meso-scale self-assembly of CaCO3 subunits. The morphology variation is influenced by the binding of β-CD-b-PLGA chains on specific crystal faces combined with the steric repulsive force of β-CD-b-PLGA chains.

Graphical abstract: Biomimetic mineralization of calcium carbonate mediated by a polypeptide-based copolymer

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Publication details

The article was received on 28 Sep 2012, accepted on 30 Nov 2012 and first published on 30 Nov 2012


Article type: Paper
DOI: 10.1039/C2TB00182A
J. Mater. Chem. B, 2013,1, 841-849

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    Biomimetic mineralization of calcium carbonate mediated by a polypeptide-based copolymer

    W. Zhu, J. Lin, C. Cai and Y. Lu, J. Mater. Chem. B, 2013, 1, 841
    DOI: 10.1039/C2TB00182A

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