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Issue 7, 2016
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Catalytic activity of polymerized self-assembled artificial enzyme nanoparticles: applications to microfluidic channel-glucose biofuel cells and sensors

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Abstract

Synthesized catalysts composed of hydrazine-bearing conducting polymer nanoparticles (poly[2,2′:5′,2′′-terthiophene-3′-yl hydrazine] (polyTHyd) and (poly[4-([2,2′:5′,2′′-terthiophen]-3′-yl) phenyl) hydrazine] (polyTPHyd)) were prepared through self-assembling monomers on gold nanoparticles (monomers–AuNPs: dia. 7.5 ± 2.0 nm). The monomers self-assembled on AuNPs were electrochemically polymerized to form conducting polymer nanoparticles, which possessed an enzyme-like catalytic activity for the reduction of H2O2. The polymer-assembled nanoparticles immobilized on microfluidic channel electrodes revealed well defined direct electron transfer (DET) processes, which were observed at +54.5/−20.9 and +64.8/+3.6 mV for polyTHyd and polyTPHyd. Glucose oxidase (GOx) and horseradish peroxidase (HRP) were immobilized on the carboxylated polyterthiophene (poly[2,2′:5′,2′′-terthiophene-3′-(p-benzoic acid)])-assembled nanoparticle layer to use as counter electrodes in the cells. The performances of microfluidic biofuel cells composed of a GOx-modified anode and cathodes of HRP and hydrazine-bearing polymer-assembled nanoparticles were compared using standard glucose, urine, and whole blood samples as fuels. The cell operated with a 10.0 mM glucose solution generated a maximum electrical power density of 0.78 ± 0.034 mW cm−2 and an open-circuit voltage of 0.48 ± 0.035 V. The cell was also examined as a glucose-sensing device, which had a dynamic range of 10.0 μM to 5.0 mM with a detection limit of 2.5 ± 0.2 μM under alternating current potential modulation.

Graphical abstract: Catalytic activity of polymerized self-assembled artificial enzyme nanoparticles: applications to microfluidic channel-glucose biofuel cells and sensors

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Publication details

The article was received on 02 Nov 2015, accepted on 15 Jan 2016 and first published on 18 Jan 2016


Article type: Paper
DOI: 10.1039/C5TA08823B
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J. Mater. Chem. A, 2016,4, 2720-2728

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    Catalytic activity of polymerized self-assembled artificial enzyme nanoparticles: applications to microfluidic channel-glucose biofuel cells and sensors

    H. Noh and Y. Shim, J. Mater. Chem. A, 2016, 4, 2720
    DOI: 10.1039/C5TA08823B

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