Issue 43, 2015

Polydiacetylene liposome-encapsulated alginate hydrogel beads for Pb2+ detection with enhanced sensitivity

Abstract

The development of a novel and simple method to trace lead ions (Pb2+) has received great attention due to its high toxicity to human health and the environment. In this paper, we describe a new polydiacetylene (PDA)-based liposome sensor for the colorimetric and fluorometric detection of Pb2+ in aqueous solution and in alginate hydrogel microbeads. In the sensor system, a dopamine group was rationally introduced into a diacetylene monomer to work as a strong binding site for Pb2+. The dopamine-functionalized monomer and 10,12-pentacosadiynoic acid (PCDA) were then incorporated into PDA liposomes in aqueous solution. After UV light-induced polymerization, deep blue colored liposome solutions were obtained. Upon the addition of various metal ions into the liposome solution, only Pb2+ could cause a distinct color change from blue to red and a dramatic fluorescence enhancement. To further improve its sensitivity and address its intrinsic aggregation, we then developed a liposome-immobilized detection system by encapsulating PDA–DA liposomes into alginate hydrogel beads through a microfluidic droplet-based method. The results showed that the PDA–DA liposome-containing hybrid hydrogel beads possessed excellent stability and high sensitivity. These interesting findings demonstrated that the PDA liposome system developed in the current study may offer a new method for Pb2+ recognition in a more efficient manner.

Graphical abstract: Polydiacetylene liposome-encapsulated alginate hydrogel beads for Pb2+ detection with enhanced sensitivity

Supplementary files

Article information

Article type
Paper
Submitted
19 Jun 2015
Accepted
10 Sep 2015
First published
14 Sep 2015

J. Mater. Chem. A, 2015,3, 21690-21698

Author version available

Polydiacetylene liposome-encapsulated alginate hydrogel beads for Pb2+ detection with enhanced sensitivity

D. Wang, Y. Wang, C. Tian, L. Zhang, X. Han, Q. Tu, M. Yuan, S. Chen and J. Wang, J. Mater. Chem. A, 2015, 3, 21690 DOI: 10.1039/C5TA04480D

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