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Issue 17, 2020
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Phenylalanine dimer assembly structure as the basic building block of an amyloid like photoluminescent nanofibril network

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Abstract

A phenylalanine dimer assembly (Phe-DA) is reported as a basic constituent of a light emitting β-amyloid type nanofibril network. The size and composition of the Phe-DA structure were characterized using various theoretical and experimental techniques. Further, the mechanism involved in the phenylalanine self-assembly process from Phe-DA to the nanofibril network was studied using optical spectroscopy and small angle X-ray scattering (SAXS). The discovery of Phe-DA and its unique optical properties may pave the way for design and development of novel theranostics against metabolite based pathalogical disorders. Further, the role of the Phe-DA structure as the elementary unit in the formation of a long range assembly structure may provide vital understanding for the development of functional materials using simple organic molecules.

Graphical abstract: Phenylalanine dimer assembly structure as the basic building block of an amyloid like photoluminescent nanofibril network

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Supplementary files

Article information


Submitted
04 Mar 2020
Accepted
02 Apr 2020
First published
03 Apr 2020

Soft Matter, 2020,16, 4105-4109
Article type
Communication

Phenylalanine dimer assembly structure as the basic building block of an amyloid like photoluminescent nanofibril network

P. Singh, N. Wangoo and R. K. Sharma, Soft Matter, 2020, 16, 4105
DOI: 10.1039/D0SM00387E

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