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Issue 39, 2019
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Styrene maleic acid copolymer induces pores in biomembranes

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Abstract

We investigated the interactions between styrene–maleic acid (SMA) copolymers and phospholipid bilayers, using confocal microscopy and surface acoustic wave resonance (SAR) sensing. For the first time we experimentally observed and followed pore formation by SMA copolymers in intact supported bilayers and unilamellar vesicles, showing that fluorescein, a water-soluble organic compound with a mean diameter of 6.9 Å, can traverse the membrane. Our findings are in agreement with recent theoretical predictions, which suggested that SMA copolymers may insert along the plane of the bilayer to form stable toroidal pores.

Graphical abstract: Styrene maleic acid copolymer induces pores in biomembranes

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Article information


Submitted
11 Jul 2019
Accepted
03 Sep 2019
First published
20 Sep 2019

This article is Open Access

Soft Matter, 2019,15, 7934-7944
Article type
Paper

Styrene maleic acid copolymer induces pores in biomembranes

M. Orwick Rydmark, M. K. Christensen, E. S. Köksal, I. Kantarci, K. Kustanovich, V. Yantchev, A. Jesorka and I. Gözen, Soft Matter, 2019, 15, 7934
DOI: 10.1039/C9SM01407A

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