ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery

Meihui Zhao; Yu Zhang; Shirui Yuan; Xiang Xu; Ziheng Wu; Zhenghong Wu; Xiaole Qi

doi:10.1039/C9SM00480G

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery†

Meihui Zhao,‡^a Yu Zhang,‡^a Shirui Yuan,^a Xiang Xu,^a Ziheng Wu,^b Zhenghong Wu*^a and Xiaole Qi

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China
E-mail: zhenghongwu66@cpu.edu.cn, qixiaole523@cpu.edu.cn

^b Parkville campus, Monash University, VIC 3052, Australia

Abstract

We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core–shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol–gel transition and DOX release when suffering enrich ATP in tumor cells.

Download options Please wait...

Supplementary files

Supplementary information PDF (690K)

Article information

DOI: https://doi.org/10.1039/C9SM00480G
Article type: Communication
Submitted: 08 Mar 2019
Accepted: 14 Apr 2019
First published: 15 Apr 2019

Download Citation

Soft Matter, 2019,15, 3655-3658

Permissions

Request permissions

ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery

M. Zhao, Y. Zhang, S. Yuan, X. Xu, Z. Wu, Z. Wu and X. Qi, Soft Matter, 2019, 15, 3655 DOI: 10.1039/C9SM00480G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Soft Matter

ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery†

Abstract

Supplementary files

Article information

Download Citation

Permissions

ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery

Social activity

Search articles by author

Spotlight

Advertisements