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Issue 11, 2017

Vesicles of 2-ketooctanoic acid in water

Author affiliations

Abstract

We report the spontaneous formation of vesicles from 2-ketooctanoic acid (KOCOOH), a single-tailed weakly acidic surfactant, in water. The vesicles were characterized using negative-staining, cryogenic transmission electron microscopy, conductivity, and atomic force microscopy. The pH effect on the vesicle formation and the stability of the vesicular structures were determined. The vesicles form at a very low concentration (ca. 1.4 mM) and within a wide pH range (ca. 2–10). Uni- and multilamellar vesicle structures are observed, which coexist in the KOCOOH solution. The hydrogen bonding between KOCOOH molecules probably plays an important role in the formation of the vesicles. Importantly, the vesicles exhibit remarkable stability upon long-term storage, and in artificial seawater. KOCOOH vesicles are a good alternative model system for protocell-like vesicles, as they are easily formed under plausible prebiotic conditions. In addition, they may have the same potential applications, such as in medicine, chemical engineering, and biotechnology, as conventional vesicles. To the best of our knowledge, this is the first report on the vesicles of single-tailed keto-acid amphiphiles.

Graphical abstract: Vesicles of 2-ketooctanoic acid in water

Supplementary files

Article information


Submitted
28 Nov 2016
Accepted
24 Feb 2017
First published
27 Feb 2017

Soft Matter, 2017,13, 2246-2252
Article type
Paper

Vesicles of 2-ketooctanoic acid in water

H. Xu, N. Du, Y. Song, S. Song and W. Hou, Soft Matter, 2017, 13, 2246 DOI: 10.1039/C6SM02665F

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