Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 11, 2017

The effect of active fluctuations on the dynamics of particles, motors and DNA-hairpins

Author affiliations

Abstract

Inspired by recent experiments on the dynamics of particles and polymers in artificial cytoskeletons and in cells, we introduce a modified Langevin equation for a particle in an environment that is a viscoelastic medium and that is brought out of equilibrium by the action of active fluctuations caused by molecular motors. We show that within such a model, the motion of a free particle crosses over from superdiffusive to subdiffusive as observed for tracer particles in an in vitro cytoskeleton or in a cell. We investigate the dynamics of a particle confined by a harmonic potential as a simple model for the motion of the tethered head of kinesin-1. We find that the probability that the head is close to its binding site on the microtubule can be enhanced by a factor of two due to active forces. Finally, we study the dynamics of a particle in a double well potential as a model for the dynamics of DNA-hairpins. We show that the active forces effectively lower the potential barrier between the two minima and study the impact of this phenomenon on the zipping/unzipping rate.

Graphical abstract: The effect of active fluctuations on the dynamics of particles, motors and DNA-hairpins

Supplementary files

Article information


Submitted
14 Nov 2016
Accepted
20 Feb 2017
First published
21 Feb 2017

Soft Matter, 2017,13, 2181-2191
Article type
Paper

The effect of active fluctuations on the dynamics of particles, motors and DNA-hairpins

H. Vandebroek and C. Vanderzande, Soft Matter, 2017, 13, 2181 DOI: 10.1039/C6SM02568D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements