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Issue 6, 2017
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Effective viscosity and dynamics of spreading epithelia: a solvable model

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Abstract

Collective cell migration in spreading epithelia in controlled environments has become a landmark in our current understanding of fundamental biophysical processes in development, regeneration, wound healing or cancer. Epithelial monolayers are treated as thin layers of a viscous fluid that exert active traction forces on the substrate. The model is exactly solvable and shows a broad range of applicabilities for the quantitative analysis and interpretation of force microscopy data of monolayers from a variety of experiments and cell lines. In addition, the proposed model provides physical insights into how the biological regulation of the tissue is encoded in a reduced set of time-dependent physical parameters. In particular the temporal evolution of the effective viscosity entails a mechanosensitive regulation of adhesion. Besides, the observation of an effective elastic tensile modulus can be interpreted as an emergent phenomenon in an active fluid.

Graphical abstract: Effective viscosity and dynamics of spreading epithelia: a solvable model

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Article information


Submitted
26 Sep 2016
Accepted
01 Jan 2017
First published
03 Jan 2017

Soft Matter, 2017,13, 1235-1243
Article type
Paper

Effective viscosity and dynamics of spreading epithelia: a solvable model

C. Blanch-Mercader, R. Vincent, E. Bazellières, X. Serra-Picamal, X. Trepat and J. Casademunt, Soft Matter, 2017, 13, 1235
DOI: 10.1039/C6SM02188C

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