Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 29, 2016
Previous Article Next Article

Aggregation behaviour of biohybrid microgels from elastin-like recombinamers

Author affiliations

Abstract

Investigation of the aggregation behavior of biohybrid microgels, which can potentially be used as drug carriers, is an important topic, because aggregation not only causes loss of activity, but also toxicity and immunogenicity. To study this effect we synthesized microgels from elastin-like recombinamers (ELRs) using the miniemulsion technique. The existence of aggregation for such biohybrid microgels at different concentrations and temperatures was studied by different methods which include dynamic light scattering (DLS), 1H high-resolution magic angle sample spinning (HRMAS) NMR spectroscopy, relaxometry and diffusometry. A hysteresis effect was detected in the process of aggregation by DLS as a function of temperature that strongly depends on ELR microgel concentration. The aggregation process was further quantitatively analyzed by the concentration dependence of the 1H amino-acid residue chemical shifts and microgel diffusivity measured by NMR methods using the population balance kinetic aggregation model.

Graphical abstract: Aggregation behaviour of biohybrid microgels from elastin-like recombinamers

Back to tab navigation

Supplementary files

Article information


Submitted
22 Apr 2016
Accepted
14 Jun 2016
First published
15 Jun 2016

Soft Matter, 2016,12, 6240-6252
Article type
Paper

Aggregation behaviour of biohybrid microgels from elastin-like recombinamers

S. Singh, D. E. Demco, K. Rahimi, R. Fechete, J. C. Rodriguez-Cabello and M. Möller, Soft Matter, 2016, 12, 6240
DOI: 10.1039/C6SM00954A

Social activity

Search articles by author

Spotlight

Advertisements