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Issue 13, 2016
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Lateral pressure-mediated protein partitioning into liquid-ordered/liquid-disordered domains

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Abstract

We have studied the contributions of stored elastic energies in liquid-ordered (Lo) and liquid-disordered (Ld) domains to transmembrane proteins using the lateral pressure concept. In particular we applied previously reported experimental data for the membrane thickness, intrinsic curvature and bending elasticities of coexisting Lo/Ld domains to calculate whether proteins of simple geometric shapes would preferentially diffuse into Lo or Ld domains and form oligomers of a certain size. For the studied lipid mixture we generally found that proteins with convex shapes prefer sorting to Ld phases and the formation of large clusters. Lo domains in turn would be enriched in monomers of concave shaped proteins. We further observed that proteins which are symmetric with respect to the bilayer center prefer symmetric Lo or Ld domains, while asymmetric proteins favor a location in domains with Lo/Ld asymmetry. In the latter case we additionally retrieved a strong dependence on protein directionality, thus providing a mechanism for transmembrane protein orientation.

Graphical abstract: Lateral pressure-mediated protein partitioning into liquid-ordered/liquid-disordered domains

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Article information


Submitted
07 Jan 2016
Accepted
12 Feb 2016
First published
12 Feb 2016

This article is Open Access

Soft Matter, 2016,12, 3189-3195
Article type
Paper

Lateral pressure-mediated protein partitioning into liquid-ordered/liquid-disordered domains

M. Frewein, B. Kollmitzer, P. Heftberger and G. Pabst, Soft Matter, 2016, 12, 3189 DOI: 10.1039/C6SM00042H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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