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Issue 4, 2016
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Enzymatically triggered rupture of polymersomes

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Polymersomes are robust vesicles made from amphiphilic block co-polymers. Large populations of uniform giant polymersomes with defined, entrapped species can be made by templating of double-emulsions using microfluidics. In the present study, a series of two enzymatic reactions, one inside and the other outside of the polymersome, were designed to induce rupture of polymersomes. We measured how the kinetics of rupture were affected by altering enzyme concentration. These results suggest that protocells with entrapped enzymes can be engineered to secrete contents on cue.

Graphical abstract: Enzymatically triggered rupture of polymersomes

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28 Jul 2015
11 Nov 2015
First published
11 Nov 2015

Soft Matter, 2016,12, 1014-1020
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Author version available

Enzymatically triggered rupture of polymersomes

W. Jang, S. C. Park, E. H. Reed, K. P. Dooley, S. F. Wheeler, D. Lee and D. A. Hammer, Soft Matter, 2016, 12, 1014
DOI: 10.1039/C5SM01881A

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