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Issue 45, 2015

Charge screening in RNA: an integral route for dynamical enhancements

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Abstract

Electrostatic interactions of RNA are at the center of determining the dynamical flexibility and structural stability. By analysing neutron scattering spectroscopy, we show that fast dynamics of hydrated tRNA on ps to ns timescales increases with stronger charge screening, while its structural stability either increases or remains largely unchanged. An unprecedented electrostatic threshold for the onset of additional flexibility is induced from the correlation between the charge-screening density of counterions and the promoted dynamical properties. The results demonstrate that the enhanced dynamical flexibility of tRNA originates from local conformational relaxation coupled with stabilized charge screening rather than governed by fluctuation of hydrated counterions. The present study casts light on the specificity of electrostatic interactions in the thermodynamic balance between the dynamical flexibility and structural stability of RNA.

Graphical abstract: Charge screening in RNA: an integral route for dynamical enhancements

Supplementary files

Article information


Submitted
20 Aug 2015
Accepted
24 Sep 2015
First published
24 Sep 2015

This article is Open Access

Soft Matter, 2015,11, 8741-8745
Article type
Communication
Author version available

Charge screening in RNA: an integral route for dynamical enhancements

J. H. Roh, M. Tyagi, P. Aich, K. Kim, R. M. Briber and S. A. Woodson, Soft Matter, 2015, 11, 8741 DOI: 10.1039/C5SM02084K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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